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[8] Patients with significant alcohol intake or thiamine deficiency also require precaution: chronic heavy alcohol use can deplete thiamine (vitamin B) and taking ALA in the setting of thiamine deficiency has been associated with serious health risks (including a condition resembling Wernickes encephalopathy)

107 A statistical analysis of three randomized controlled trials with a combined total of 168 participants found curcumin supplementation, at doses of 5001,500 mg per day, led to improvements in fasting glucose, insulin levels, measures of insulin sensitivity, and HDL- and total cholesterol in women with PCOS

Abnormal electroencephalogram (EEG) patterns have also been reported in vitamin B 6 -deficient adults

Papademetriou IT, Porter T

doi: 10.1055/a-1681-2047