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Notably, the roles performed by these cells in the disruption of the BBB by LPS may be interpreted as a succession or amplification, implying that the effects on the structure and function of the BBB by LPS are largely or even entirely through the mechanisms detailed in the direct actions section

Focused ultrasound can open the BBB and enhance the penetration of aducanumab (Rezai et al., 2024)

One of the most important aspects to understand is that recovery occurs in three primary stages

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In addition, administration of a JAK/STAT3 (Janus kinase-signal transducer and activator of transcription 3) signaling pathway inhibitor attenuated mechanical and thermal hyperalgesia, inhibited reactive astrocytes, and restored normal expression levels of astrocytic GLT-1 in the spinal dorsal horn of NDRG2-overexpression rats