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Cracked lips are usually a mild symptom that occurs as a result of environmental factors, personal habits such as licking your lips, or conditions such as mild dehydration and the common cold

Part B, Critical Reviews, 16 (7), 399-451

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Matrix metalloproteinases (MMPs) are up-regulated by pro-inflammatory cytokines, as well as by acute phase proteins like serum amyloid A (SAA), with counter-regulatory inhibition by IL-4 and IL-13, and released into the circulation from damaged vascular endothelium

Wide radical excision is the standard treatment for primary acral melanoma, similar to other cutaneous melanomas