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Some cases of increased INR and prothrombin time have been reported in patients receiving PPIs and warfarin concomitantly

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Testing of two batches by the UK's Medicines and Healthcare products Regulatory Agency (MHRA) found the products, which have now been pulled from sale, contained between 1.5mg and 1.7mg of melatonin
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doi: 10.1016/j.fitote.2015.02.012
