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Under ER stress, the integrated stress response (ISR) pathway is activated, leading to the phosphorylation of eIF2 and subsequent upregulation of ATF4, a transcription factor that increases CHAC1 expression

Sep 5 2023;12(17):e030739

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doi: 10.1186/s13287-024-04126-z 148 SunLYangNChenBBeiYKangZZhangCet al
