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Some medications can be prescribed independently, while others require physician supervision

(Neelakantan et al., 2018) observed that systemic administration of NNMTi to mice with diet-induced obesity markedly attenuated WAT mass and body weight, diminished adipocyte volume, and reduced plasma TC levels

The answer is short and simple: We dont know

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When NNMT is blocked, these fat cells shift toward a more metabolically active phenotype