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CNS Penetration of GLP-1RAs: Implications for Addiction As previously reviewed, numerous preclinical studies have demonstrated that GLP-1RAs can modulate drug-related behaviors across a variety of addiction models, including those involving alcohol, nicotine, psychostimulants, and opioids

Gonadal steroids can also influence GLP-1R expression in the brain and other tissuesin the whole hypothalamus, for example, the highest GLP-1R expression is found in the late proestrus stage (46), providing further mechanistic support for potentially higher sensitivity to GLP-1 effects during this phase of the cycle (33, 47)