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Preclinical and observational data suggested possible benefits, spurring rigorous clinical testing

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Perhaps, we will be able to help some people to avoid side effects with one medicine by using a different one, or by using lower doses with specific combinations

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Key numbers (T2D, semaglutide vs matched controls): NAION RR at 1/3/5 yrs = 1.00 / 0.84 / 0.70

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Nausea, constipation, diarrhea, and low appetite are common GLP-1 side effects

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The UKs MHRA recently issued guidance reminding patients using the GLP-1 agonist tirzepatide, who are also on oral contraceptives, that a barrier form of contraception should also be used.

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