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Description
Although the specific mechanism for therapeutic effects of biotin in biotin-thiamin-responsive basal ganglia disease remains unknown, lifelong high-dose supplementation with a combination of biotin and thiamin is the recommended treatment (31)
For some people, that feels efficient

Typical starting doses are 75 mg twice daily, titrated as needed

You really have to start with the foundation

Many patients notice improved appetite control, energy, and better blood pressure or blood sugar within the first 1-2 months