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"What it's really doing is changing people's lives - treating the patient before they have the disease," she says

For chronic weight management, the FDA-approved semaglutide product is Wegovy (also Novo Nordisk), at a higher dose

As a general procedure, the investigators directly performing the experimental procedures were not blinded to the group allocation, but data analyses by senior authors were largely conducted independently to avoid potential bias

By combining genetic insights with your clinical history and initial medication response, you and your provider can have a more informed conversation about portion sizes, macronutrient balance, and food choices that align with your unique peptide metabolism and tolerability profile during GLP-1 treatment

The results from this landmark study across 37 countries provide strong evidence that semaglutide can help patients with MASH by not only improving liver health, but also addressing the underlying metabolic issues that contribute to the disease, said Sanyal, who is the lead author on the new paper and is also a professor of medicine at the VCU School of Medicine