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Whether this risk applies to humans is not established, but the warning is required by the FDA

Doses above 2.4 mg weekly remain investigational without FDA approval for standard clinical use

Metabolic Flexibility GIP and glucagon receptor activation complements GLP-1 appetite suppression with enhanced energy expenditure and improved lipid metabolism signalling

184 Conclusion From the data presented, it can be concluded that the derivatives of Cannabis sativa can produce an increase in lipolysis, thermogenesis, and a reduction in lipogenesis, playing a role in the regulation of body weight, through action on several receptors

Cardioprotective functions in heart failure Both preclinical and clinical studies have demonstrated beneficial effects of GLP-1 on the failing heart