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The availability of compounded GLP-1 options has been subject to ongoing legal challenges from brand manufacturers, making the long-term availability of these alternatives uncertain

Dulaglutide is a long-acting GLP-1RA used for T2DM with demonstrated cardiovascular benefits.[10] Liraglutide, another long-acting GLP-1RA, is used for T2DM and obesity management and is under investigation for Alzheimers disease and metabolic-associated hepatic steatosis.[4] Lixisenatide, a short-acting GLP-1RA, shows comparable efficacy to exenatide and liraglutide for T2DM management, and is now combined with insulin glargine.[23] Semaglutide, available in injectable and oral forms, has demonstrated benefits in promoting weight loss, reducing risk of cardiovascular events, and slowing progression of diabetic CKD.[24] Finally, tirzepatide is a dual agonist for receptors of GLP and glucose-dependent insulinotropic polypeptide (GIP), a hormone released from the intestines in response to macronutrients.[25] These two mechanisms of action have synergistic glucose-lowering and weight loss effects with lower side effect rates than other GLP-1RAs.[25] Tirzepatide has also been shown to result in blood pressure reduction, obstructive sleep apnea control, and improved cholesterol in T2DM patients.[5] Table

Pep is a free GLP-1 tracking app that logs doses, weight, side effects, nutrition, and progress photos without a subscription for its core features

Ultimately, you can be well-informed in your food purchasing decisions and make the best choice for your health and your wallet, especially when taking GLP-1 medications

10.1016/j.molmet.2016.09.005 23 FosgerauK.HoffmannT