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Dosing starts low at 0.25mg weekly and gradually increases every 4 weeks until reaching the therapeutic dose, typically 1 to 2.4mg weekly

Claim 1: Homozygous loss-of-function mutations in the myostatin (MSTN) gene cause gross skeletal muscle hypertrophy in humans

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This review adopts a structured narrative framework designed to integrate mechanistic, translational, and clinical insights across heterogeneous study types