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Gastric hypoglycaemia-an important concept in diabetes management

Structural determinants of binding the seven-transmembrane domain of the glucagon-like peptide-1 receptor (GLP-1R)

doi: 10.1172/jci.insight.133429 [DOI] [PMC free article] [PubMed] [Google Scholar] 146

-cell-selective knockout of the GLP-1R in mice with impaired glucose tolerance after intraperitoneal injection of glucose and exogenous supplementation of GLP-1 did not induce insulin secretion, but glucose tolerance returned to normal after oral glucose, suggesting that the extra-islet GLP-1R plays a regulatory role in oral glucose tolerance (Smith et al., 2014)

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