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Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as add-on to metformin in patients with type 2 diabetes in SUSTAIN China: A 30-week double-blind phase 3a randomized trial

The Chief Scientific Advisor at Novo Nordisk, Lotte Bjerre Knudsen, was the key force who pushed hard to develop GLP-1 drugs for treating obesity and subsequently for Alzheimers

When you eat, your intestines release GLP-1, which kicks off a cascade of important actions

1416 Randomized clinical trials showed that liraglutide, an older generation of GLP-1RAs, reduced whole cortical gray matter, frontal, temporal, and parietal lobe volume compared to placebo in patients with early to moderate AD

Specific amino acid substitutions confer resistance to dipeptidyl peptidase-4, a primary clearance pathway for native GLP-1, while attachment of a C18 fatty acid side chain promotes strong, reversible binding to serum albumin