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The supplementation question is secondary to the measurement question
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The primary concern centres on the lack of robust clinical data

Semaglutide can restore the decreased gut microbiota diversity in db/db mice and reverse the changes in specific bacterial levels induced by a high-fat diet (HFD) (Somm et al., 2021)

173 Its research findings were recently presented orally at the 83rd Scientific Sessions of the American Diabetes Association and published in the New England Journal of Medicine
