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That matches what we know clinically: pharmacotherapy works best inside structured behavioural support, not instead of it or pitched against it

[DOI] [PMC free article] [PubMed] 35.Chao AM, Tronieri JS, Amaro A, Wadden TA

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The mode of action for AMG133 is believed to involve this bispecific molecule simultaneously binding to both the GIP- and GLP-1 receptor, where it is demonstrated to increase cAMP production and induce internalization of co-localized GIP and GLP-1 receptors