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In recent years, oral semaglutide, the first-in-class oral GLP-1RA offering equipotent hypoglycemic effects to injectable GLP-1RAs with a low risk of hypoglycemia, has been approved for the treatment of T2DM [7, 8], positioning it as a potential therapeutic agent for managing T2DM

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This faster escalation reflects retatrutides triple-agonist mechanism: the glucagon receptor component may improve tolerability at higher incretin doses by providing additional metabolic pathways for the body to utilize the compound