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Differential Diagnosis Other conditions or situations that can cause similar symptoms to Cushings syndrome include: Strenuous exercise or physical stress Sleep apnea Depression, anxiety and other psychological disorders Pregnancy Chronic pain Emotional or physical stress Uncontrolled diabetes Excessive alcohol intake Obesity Diagnostic tests can help to make a differential diagnosis and investigate the role of the cortisol hormone in precipitating the changes, which is characteristic of Cushings syndrome

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