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Ann Intern Med (2003) 139(11):9302.10.7326/0003-4819-139-11-200312020-00012 5 National Institutes of Health

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Currently, GLP-1R agonists are mainly targeted on the endogenous GLP-1R signaling system, which causes GLP-1R agonists to have many pharmacodynamic characteristics like GLP-1

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The more common side effects range from nausea to belly pain and diarrhea

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They work by mimicking naturally occurring gut hormones that regulate appetite and blood sugar

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Oral tablets: Rybelsus, taken once daily

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