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Currently approved DPP-4is for T2DM include teneligliptin, alogliptin, linagliptin, saxagliptin, sitagliptin, and vildagliptin

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One study from earlier this year says more than half of 20,274 patients who lost at least five pounds on semaglutide were "around the same weight" one year after coming off the medication

2.2.5 Metabolic reprogramming Metabolic reprogramming refers to the process in which cells, under specific physiological and pathological conditions, systematically adjust and transform their metabolic patterns to adapt to changes in the external environment and to meet their own needs for growth and differentiation, by engaging various bioenergetic routes, such as glucose utilization, lipid metabolism, and amino acid metabolism (Xia et al., 2021