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In other words, the gastrointestinal side effects were milder and less frequent than what researchers typically see with GLP-1 and GIP agonists

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[DOI] [Google Scholar] 14.Dahl D, Onishi Y, Norwood P, Huh R, Bray R, Patel H, Rodrguez

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doi: 10.3390/nu11051136

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Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects

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Setmelanotide is FDA approved for ages 6 years and older to treat monogenic obesity due to variants that are pathogenic, likely pathogenic or variant of unknown significance (VUS) in POMC (pro opiomelanocortin), PCSK1 (proprotein convertase subtilisin/kexin type 1), LEPR (leptin receptor) and Bardet Biedl Syndrome (BBS)

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