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Moreover, although we applied the PRISMA framework and screened studies systematically, the body of available evidence included heterogeneous study types, ranging from randomized controlled trials and observational studies to animal experiments and narrative reviews

Preclinical studies have demonstrated that triple receptor agonists (RAs) activating all three receptors (GLP-1, GIP, and GCG) produce more pronounced weight loss than dual agonists targeting only two receptors [6]

average [SD] BMI, 37.0 [2.9]) completed the low-calorie diet and were then randomly assigned to the exercise group ( n = 48), liraglutide group ( n = 49), combination group ( n = 49), or placebo group ( n = 49)

However, the ovarian structure in PCOS mice is characterized by more cystic follicles, thinner granulosa cell layers in the follicles, and fewer corpora lutea