tobacco row mountain Top of Tobacco Root Mountains, South Willow

Hope this helps and gives you a place to start

Indeed, mounting observational evidence has reported that tobacco use was associated with alterations in the gut microbiota composition [10,11,12]

The Korea Herald

The affected group not only exhibited a higher prevalence of residing in smoking households, but urothelial carcinoma was diagnosed in 35.5% of dogs with measurable urinary cotinine levels, compared to only 15.5% in those with undetectable cotinine concentrations (p=0.016) 3

Although the male-to-female ratio of the ever-smoker population was much higher in the present study than in Western studies, the sex ratio in the never-smoker population was similar to that found in Western and Taiwanese studies (1.52:1)