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For the heavy smoker, it may be depressing to be relegated to the outdoors in order to have a cigarette, a situation exacerbated by bad weather

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Expression of the intestinal marker Cdx2 in the columnar-lined esophagus with and without intestinal (Barretts) metaplasia

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This increasing tolerance further deepens the addiction and makes it harder to quit, as smokers continually seek out the nicotine rush