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In studies that further elucidated the mechanism underlying HAP1s regulation of BDNF transport, it was found that endogenous HAP1 colocalizes with proBDNF and sortilin in cultured cortical neurons

Outcome measures including the Revised Fibromyalgia Impact Questionnaire (FIQR), Hospital Anxiety and Depression Scale (HADS), 12-item Short-Form health survey (SF-12), and pain Visual Analog Scale (pain-VAS) were fulfilled by patients before and after the treatment

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B12 injections are not meant to replace a healthy lifestyle

The primary endpoint was the blinded assessment of the percentage over the total target (that is, time with either dyskinesia or bradykinesia), recorded by actimetry at home using a wristwatch