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It is generally believed that activation of mTORC1 by specific amino acids, notably leucine, starts with its recruitment to the lysosomal membrane by GTPases called Rags, which are concentrated there as heterodimers consisting of RagA or RagB combined with RagC or RagD

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Holocarboxylase Synthetase Deficiency Deficiency in holocarboxylase synthetase is an autosomal recessive disorder that results in multiple carboxylase deficiency

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