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As we grow older, our internal production often begins to decline, which is why many health-conscious adults look to supplementation to maintain optimal levels

BMC Complement Altern Med 16:16 [DOI] [PMC free article] [PubMed] [Google Scholar] Germolec DR, Shipkowski KA, Frawley RP, Evans E (2018) Markers of inflammation

RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy

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Thus, a dose-dependent decrease in enzyme activity was probably due to competitive inhibition which occurs when there are many compounds completing for several detoxification enzymes, causing an increase in toxic load (Liska et al ., 2006)