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Mitochondrial metabolism and KRASMAPK axis in CRC chemoresistance Although chemotherapeutic agents such as 5-FU, oxaliplatin, and irinotecan remain central to CRC treatment, the metabolic adaptability of tumor cells continues to undermine their long-term efficacy [23]

The immune systems cholinergic anti-inflammatory pathway is mostly regulated by stimulating nicotinic receptors and, more specifically, selective 7 nicotinic acetylcholine receptors (7-nAChR)