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& Wood, S
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SCFA metabolites, such as acetate, propionate, and butyrate, can act on fatty acid receptors in epithelial, enteroendocrine, and neuronal cells, and they could affect the central nervous system in experimental model organisms (53, 54)
Replacement of Sec46 by a cysteine or mutation of any of the 3 other amino acids of the catalytic site results in an abrogation or a diminution of GPX4 enzymatic activity [1]
