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This site has also been shown to be a site of mechanistic target of rapamycin complex 2 (mTORC2) phosphorylation [22]

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221 Furthermore, PTBP1 hyperlactylation in GSCs promotes glioma progression and supports the maintenance of GSCs by inhibiting its interaction with TRIM21 and enhancing its RNA-binding affinity and stabilizing PFKFB4 mRNA, which in turn accelerates glycolysis, eventually forming a feedback loop that exacerbates tumorigenesis

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Cell 58 , 707718 (1989)
