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LAT1 is highly expressed in the brain, testes, ovaries, pancreas, and placenta, whereas it is downregulated in the lungs, heart, and liver [37]

Between the two neuropeptide effects on ACTH release, CRH is the more dominant effect although there is some residual HPA axis activation in female CRH knockout mice (59)

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13 Studies investigating the status of claudins and other TJ-associated proteins in human biopsy specimen from chronic inflammatory conditions (Inflammatory Bowel Disease (IBD)) 14 have demonstrated differential changes in their total cellular content and/or distribution (see Table 1)