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Seizure medications such as phenytoin and phenobarbital, as well as diabetes medications like metformin, can lower B12 levels over time

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doi: 10.2337/db05-0585

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It is not found in nature in its isolated form but is derived from a larger protective protein present in gastric secretions

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Vitamin B12 Injections B12 shots are recommended weekly for 5 weeks, then monthly for at least 6 months

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