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In view of the information from several recent studies (see section 8.6), these plants present a very interesting system in which to analyze responses to biotic and other stresses

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Beyond safety, clinical effectiveness remains very diverse and contentious, with no evidence of a molecular explanation and conflicting therapeutic advantages (333)

These uricosuric drugs function, at high doses, by competing for urate reuptake from the glomerular filtrate via SLC22A12 and, therefore, reduce renal reabsorption of uric acid allowing for increased excretion in the urine