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Our results indicated that the redox stress mediated by the accumulation of fumarate caused by the loss of Fh1 leads to senescence

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Though both produced stable, reproducible cancer cell killing performance with inevitable adverse effects [197], radicals have been considered to be more feasible for treating complex syndromes such as cancers [195, 196], whereas non-radical components take the leading roles in applications such as disinfection [267, 268]

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