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[PubMed] [Google Scholar] 91

303 Gastrointestinal adverse reactions, including nausea and diarrhea, are significant at the dose of 10 mg

By 2020, DON had advanced through phase III clinical testing in more than 700 patients, but dose-limiting gastrointestinal toxicity and limited efficacy curtailed further development [167]
Pandolfi, Pro-senescence therapy for cancer treatment

Furthermore, a review of associated research papers (if available) was conducted to supplement the metadata obtained
