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[17] Studies into cardiovascular endpoints, however, were largely disappointing

We assessed the clinical symptoms, mortality and weight of the CDI model mice as previously described 35,37,38

Percent fractional shortening (%FS = (LVID;d-LVID;s)/LVID;d 100) and percent ejection fraction (%EF = (LV Vol;d-LV Vol;s)/LV Vol;d 100) were calculated as systolic cardiac functional indices in vehicle- and METH-treated mice

40 Due to the adverse events of peg-interferon plus ribavirin, patients with contra-indications to peg-interferon plus ribavirin treatment are also not candidates for boceprevir- or telaprevir-based triple therapy

Some studies show that MOTS-c treatment helps restore metabolic homeostasis in these models