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However, outside of the natural aging process, there are certain inflammatory factors that are believed to speed up premature greying

This can be viewed as a form of homeostatic plasticity, where the CAS enhances its activity to maintain a relatively constant level of neural firing in response to diminished peripheral sensory input

After metabolic pathway analysis, it was found that the antidepressant mechanism of ZZCD on CUMS rats related to the improvement of brain metabolism in Phenylalanine, tyrosine and tryptophan biosynthesis, Glutathione metabolism, Phenylalanine metabolism, Lysine degradation, Cysteine, and methionine metabolism, Tyrosine metabolism, and Tryptophan metabolism

doi: 10.1016/s0891-5849(96)00432-7