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The compound's mechanism of action operates through HGF mimetic activity, binding to c-Met receptors expressed on neurons and triggering intracellular signaling cascades that promote synaptogenesis, neurite outgrowth, and dendritic spine formation

doi: 10.3389/fimmu.2026.1807087 Received 09 February 2026 Revised 18 April 2026 Accepted 27 April 2026 Published 14 May 2026 Volume 17 - 2026 Edited by Marit van Buuren, BioNTech US, United States Reviewed by David OSullivan, Victoria University of Wellington, New Zealand Yanying Yang, Fudan University, China Updates Copyright 2026 McPhedran, Zhao and Lum

Null polymorphisms of GSTM1 , GSTP1 and GSTT1 genes can result in a diminished gene expression level and a reduced enzymatic activity of GST

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the second was lactulose, which was able to get through the IEB only when its integrity was lost