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Furthermore, the year of publication and dosage were found not to be a source of heterogeneity (Table 4)

They found that rats who had 6-OHDA injected into their brains, increased IL1, IL6 and TNF release within the striatum, whereas inflammatory mediators were reduced by oral ingestion of valproic acid at a dose of 50 mg/kg and reduced degeneration of neurons within the striatum because of VPA's histone deacetylase inhibitory and anti-inflammatory effects (Ximenes et al., 2015)

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