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T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2

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The ability to incorporate systemic modifiers such as diabetes, obesity, or aging into these models further enhances their relevance, allowing researchers to explore how systemic inflammation, metabolic dysregulation, or immunosenescence influences disease susceptibility and the capacity for repair [71, 72, 73, 74, 75]

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SLC7A11 expression also increased levels of intracellular CYS and sugarCYS conjugates and was inhibited by erastin treatment (Extended Data Fig