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This means it increases the amount of serotonin and norepinephrine available in the brain, which may reduce the transmission of pain signals from the brain, and provide relief from musculoskeletal pain

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However, a distal ARE element located ~ 3.1kb upstream of the transcriptional start site of human GCLC was found to mediate constitutive and -NF inducible expression in HepG2 cells (a human hepatoma cell line) [78]

It is not surprised that if we raised cytosolic GSTP level through GSTP plasmid transfection or treated mice with GSTP protein, the excessive inflammatory responses and mortality rate of CLP-induced sepsis were significantly reduced

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