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Gastroenterology 84 ShibataT.OhtaT.TongK

Redox Signal 11 , 26852700 (2009)

[16] Waddington suggested visualising increasing irreversibility of cell type differentiation as ridges rising between the valleys where the marbles (analogous to cells) are travelling

Any decline in redox enzymes may increase free radical generation with subsequent induction of lipid peroxidation, protein oxidation, and DNA/RNA degradation 557,558,559

Certain environmental factors such as aluminum exposure (that can aggregate A) (Kawahara and Kato-Negishi, 2011), and raw copper exposure in drinking water (that can exacerbate AD by suppression of LRP1) (Brewer, 2014
