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The first reported observation that GTPases influence eryptosis was by Attanzio et al., who showed that NSC23766, a specific inhibitor of Rac1 GTPase, was able to ameliorate oxysterol-induced eryptosis [180]

Prescribers should be aware that hydroxocobalamin is contraindicated in patients with a known hypersensitivity to cobalt or any other component of the injection solution

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Intraperitoneal route: Used primarily in animal studies, this route allows rapid systemic absorption

they primarily manifest as xerostomia and dry eye, which are often accompanied by systemic complications, including lung, renal, and nervous system involvement and lymphoma [5]