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On the other hand, administration of glucagon receptor antagonists can cause metabolic effects (weight loss, i.e
[0150] Embodiment 143 : The immunoconjugate of embodiment 141, wherein the drug comprises a drug selected from the group consisting Monomethylauristatin F (MMAF), Auristatin E (AE), Monomethylauristatin E (MMAE), vcMMAE, and vcMMAF
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In agreement with this positive connection between glutaminolysis and mTORC1, FOXO-mediated expression of GS inhibits mTOR signaling by blocking its lysosomal translocation [76]
