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Neurotoxicity also plays havoc by upsetting the equilibrium of the body by interfering with natural neurochemistry, causing over or under-activity of certain organs, glands, and tissues

A number of substrate concentrations are fixed in the model and in all the simulations reported below

While significant breakthroughs have been achieved in multimodal modulation of mitochondrial biogenesis, mitophagy, and dynamics, persisting challenges include incomplete elucidation of molecular regulatory networks and genetic foundations, limitations of single-pathway intervention strategies in achieving multi-target coordination, and technical barriers imposed by the selective permeability of the blood-brain barrier (BBB) that hinder clinical translation of mitochondrial-targeted therapies (Meng et al., 2024)

Adding a tyrosinase inhibitor like kojic acid or arbutin may complement glutathione's redox mechanism

doi: 10.1042/BCJ20170589