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Oncogenesis 7 , 8 (2018)
Many inhibitors also have off-target effects, which become more pronounced at high concentrations
However, recent studies in metabolically competent HepaRG cell lines [23] and primary human hepatocytes [66] have confirmed that exposure to high levels of APAP result in GSH depletion, APAP protein adduct formation in mitochondria and organelle dysfunction accompanied by oxidant stress, resulting in necrotic cell death in human cells as demonstrated earlier in mouse models
Colorant : Carbonate de Calcium
Dev S, Kruse RL, Hamilton JP, Lutsenko S
