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The accumulation of fat can lead to a dysfunction in the biosynthesis of L-carnitine (Figure 1) in the liver thus inducing a negative feedback loop, whereby less L-carnitine is produced which leads to enhanced impairment of fatty acid oxidation re-enforcing fatty liver disease

This affects both: Endocrine function insulin and glucagon deficiency Exocrine function loss of digestive enzymes Common causes include: Chronic pancreatitis Pancreatic surgery (partial or total removal) Pancreatic cancer Cystic fibrosisrelated diabetes Severe acute pancreatitis, trauma, or haemochromatosis Why Its Different Unlike Type 1 or Type 2, patients with Type 3c have: Insulin deficiency (like Type 1) Impaired glucagon response higher risk of severe hypoglycaemia Exocrine insufficiency malabsorption, weight loss, vitamin deficiencies Standard Type 2 therapies may fail if the underlying pancreatic disease is ignored

This is reflected in some preliminary studies demonstrating that reducing or discontinuing antihypertensive medication in some patients is not only possible, but necessary [196]

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710GO 710GO is an orally available cyclic peptide discovered by Endevica Bio and under development by Kalohexis