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[ 323 ] Instead, deletion of Progesterone receptor membrane component 2 (PGMRC2) in brown fat, an intracellular haem chaperone, decreases labile haem in the nucleus and improves the stability of BACH1, which is the haemresponsive transcriptional suppressor, resulting in higher fasting glycemia, reduced glucose tolerance and insulin sensitivity, hyperlipidemia, and exacerbated liver steatosis in mice with HFD