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Conversely, cholecystokinin-tetrapeptide (CCK-4), a synthetic analog of the endogenous peptide, has been reported to induce anxiety- and panic-like symptoms in both animal models and healthy human subjects [47]

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Compared to cytosolic NADK (cNADK), mitochondrial NADK (mNADK) has a distinctive feature that it can directly phosphorylate nicotinamide adenine dinucleotide (NADH) to generate NADPH to alleviate oxidative stress in mitochondria